Is It Safe to Drink Alcohol While Taking Seroquel? Risks and Considerations

When it comes to managing mental health conditions like schizophrenia, bipolar disorder, or depression, medications like Seroquel play a crucial role in treatment, helping people to live more normal and manageable lives. When individuals are put on new medications, they wonder how it may affect their daily habits and way of life, including whether they can drink alcohol while taking their medication. Regarding Seroquel and drinking alcohol, it’s generally not advisable or considered safe.
Mixing Seroquel with alcohol can have serious consequences, ranging from heightened sedation and impaired motor skills to dangerous changes in heart rate, blood pressure, and mental alertness. These effects not only put physical safety at risk but can also undermine the progress in treatment and effective interventions for alcohol abuse.
Additionally, mixing this medication with alcohol also increases the risk of developing an alcohol use disorder and worsening mental health conditions that Seroquel is meant to treat. There is also a risk associated with overdose due to the amplified sedative effects of mixing both substances.
Understanding the risks and dangers of mixing Seroquel with alcohol can help individuals on this medication make informed decisions about their health. It is crucial to seek out alcohol addiction treatment if you are unable to stop drinking alcohol before beginning this medication.
Drug rehab programs with private rooms also provide effective evidence-based therapies and teach coping strategies to manage alcohol cravings, as well as dual diagnosis programs to treat underlying mental health conditions.
What Is Seroquel (Quetiapine)?
Seroquel, the brand name for quetiapine, is a prescription medication that belongs to a class of drugs called atypical antipsychotics. It is primarily used to treat schizophrenia, bipolar disorder, and major depressive disorder (MDD).
According to WebMD, quetiapine affects certain neurotransmitters in the brain, particularly dopamine and serotonin, which are involved in mood, behavior, and perception. Lower doses of Seroquel act mostly on histamine and serotonin, which can be used off-label for insomnia or anxiety, while high doses have a strong antipsychotic effect and are used for schizophrenia.
While effective for managing psychiatric symptoms, Seroquel can cause a range of side effects, some mild and others potentially serious. Many people taking Seroquel may experience side effects that include:
- Drowsiness or sedation, which is very common and sometimes severe
- Dizziness
- Dry mouth
- Constipation
- Weight gain
- Increased appetite
- Low blood pressure upon standing
In some cases, Seroquel can cause more severe reactions that require medical attention, such as:
- Irregular heartbeat
- Seizures
- High blood sugar and diabetes
- Increased cholesterol or triglyceride levels
- Suicidal thoughts or behaviors

How Does Seroquel Work in the Brain?
As reported by MedicalNewsToday, Seroquel is believed to influence the balance of specific neurotransmitters in the brain, particularly dopamine and serotonin. People who have schizophrenia and bipolar mania often exhibit elevated dopamine levels.
Excess dopamine can lead to hallucinations or delusions, hallmark symptoms of schizophrenia. By modulating the activity of various neurotransmitters, Seroquel aids in calming racing thoughts, stabilizing mood fluctuations, and alleviating agitation or hallucinations.
Seroquel works by blocking dopamine D2 receptors in the brain, diminishing the impact of dopamine and alleviating symptoms such as hallucinations, delusions, and agitation.
Additionally, it inhibits serotonin 5-HT2A receptors, which helps in mood regulation and contributes to its antidepressant and antipsychotic properties. This medication may also mitigate some side effects commonly associated with older antipsychotics, like movement disorders.
Furthermore, Seroquel affects other neurotransmitters, including histamine (H1) receptors, leading to sedation.
What sets Seroquel apart is its dose-dependent nature. At lower doses, it primarily serves as a sedative, aiding sleep and reducing anxiety; at moderate doses, it can enhance mood and alleviate depressive symptoms; while at higher doses, it delivers more potent antipsychotic effects, beneficial for conditions such as schizophrenia or mania. It also interacts with various receptors in the brain related to sleep, blood pressure, and appetite, which accounts for side effects like drowsiness, dizziness, or weight gain.
What Happens When You Combine Seroquel With Alcohol?
Both substances act as central nervous system depressants, which can significantly enhance sedative effects when taken together. This combination can lead to impaired coordination, slower reaction times, and decreased alertness, making situations more hazardous, especially with alcohol present. In sensitive individuals or at high doses, these sedative effects may even lead to respiratory suppression, posing serious health risks, including overdose and death.
According to GoodRX, both Seroquel and alcohol cause changes in the brain when consumed, as they affect dopamine in the brain but in opposite ways. Alcohol increases dopamine in the brain, which could combat Seroquel’s actions, potentially making it less effective. Additionally, Seroquel is prescribed for mental health conditions like bipolar disorder, schizophrenia, or depression, which can be made worse when drinking alcohol.
Furthermore, alcohol can intensify Seroquel’s side effects, such as low blood pressure (leading to dizziness or fainting), nausea, heart rhythm disturbances, and memory issues. The liver processes both substances, and their combination can increase the risk of liver damage, particularly with prolonged use.
Additionally, this mix heightens the likelihood of developing or worsening substance abuse problems, including alcoholism, as it disrupts brain chemistry, increases sedation, and fosters unhealthy coping strategies that may lead to addiction.

What Alternative Strategies Can Help Manage Alcohol Cravings While on Seroquel?
Individuals facing mental health challenges such as schizophrenia, bipolar disorder, depression, and anxiety often find themselves grappling with substance misuse, including drugs and alcohol. Many resort to these substances as a means of self-medication, which can lead to a substance use disorder.
It’s important to note that combining Seroquel with alcohol can pose serious risks, making it essential for those with alcohol use disorder (AUD) to seek effective ways to quit drinking and avoid triggers for alcoholics.
Successfully managing alcohol cravings while on Seroquel involves a blend of medical, psychological, and lifestyle approaches. Although Seroquel is not specifically designed for alcohol dependence, it may help alleviate cravings in individuals with concurrent mental health issues.
Comprehensive rehabilitation programs offer the most supportive environment for safely and effectively managing these cravings, typically incorporating medical oversight, therapy, and personalized support systems. Strategies to help control alcohol cravings while taking Seroquel include:
- Behavioral Therapy – Engaging in talk therapy, such as Cognitive Behavioral Therapy (CBT), can assist individuals in identifying and altering the thought patterns that lead to substance use, while also equipping them with coping mechanisms for cravings and triggers
- Medication Management – Prescribing medications like naltrexone or acamprosate, which are approved for alcohol dependence, alongside Seroquel can further support recovery.
- Support Groups – Participating in peer support networks like Alcoholics Anonymous (AA) or SMART Recovery can offer motivation, accountability, and a sense of belonging.
- Healthy Lifestyle Habits – Adopting a consistent sleep routine, consuming a nutritious diet, and staying physically active can help stabilize mood and diminish the desire to self-medicate.
- Mindfulness and Stress Reduction – Engaging in practices such as meditation, yoga, and deep breathing exercises can effectively lower stress levels and emotional triggers that lead to cravings.
Contact WhiteSands Treatment for More Information on Seroquel and Drinking Alcohol and Addiction Treatment Options
If you or someone you care about is using Seroquel and drinking alcohol, it’s essential to recognize the dangers and seek assistance from qualified professionals if you’re struggling to stop drinking. Mixing these substances can diminish the effectiveness of the medication, cause severe health issues, and heighten the risk of addiction.
At WhiteSands Treatment, we provide personalized care designed to meet your unique needs, including medically supervised detox, tailored therapy, holistic methods, and strategies for long-term recovery. We specialize in evidence-based addiction treatment that addresses both substance use and the underlying psychological factors that contribute to it.
Reach out to WhiteSands Treatment at 877-855-3470 today to consult with an experienced treatment specialist about the critical need to stop drinking while on Seroquel and to discuss your options for addiction treatment.
External Sources
- WebMD – Quetiapine (Seroquel) – Uses, Side Effects, and More
- MedicalNewsToday – Seroquel (quetiapine)
- GoodRX – Seroquel and Alcohol: What You Should Know About Mixing Alcohol with Antipsychotics
If you or a loved one needs help with abuse and/or treatment, please call the WhiteSands Treatment at (877) 855-3470. Our addiction specialists can assess your recovery needs and help you get the addiction treatment that provides the best chance for your long-term recovery.