Phentermine Withdrawal: Common Symptoms and Treatment Options

Carrying excess weight can significantly heighten the likelihood of various health complications, including heart disease, type 2 diabetes, and issues related to joints and muscles. For many, shedding a substantial amount of weight can be quite challenging. Still, medications such as phentermine can effectively curb appetite in the short term, aiding individuals in enhancing their health when combined with proper diet and exercise.
However, because phentermine has stimulant-like properties, prolonged use or higher-than-recommended doses can lead to dependence and phentermine withdrawal symptoms.
Like many stimulant medications, suddenly stopping this medication can result in phentermine withdrawal symptoms, which may include fatigue, depression, intense hunger, and mood fluctuations. The journey of stopping phentermine can be both physically and emotionally taxing, potentially leading to relapse or the misuse of other substances to ease discomfort.
Recognizing the signs and symptoms of phentermine withdrawal is crucial for safe management. Thankfully, there are treatment options at our Florida prescription drug addiction treatment center that not only facilitate a smoother transition off the medication but also support long-term weight loss goals.
What Is Phentermine?
Phentermine is a prescription drug that falls under the category of anorectics, which are appetite suppressants. As noted by GoodRX, it functions as a sympathomimetic stimulant. While the precise mechanism behind its weight loss effects remains unclear, it is believed to promote the release of norepinephrine and dopamine in the brain, leading to decreased hunger and enhanced feelings of fullness.
Typically, it is prescribed for short-term use, ranging from three to 12 weeks, to assist individuals who are overweight or obese in their weight loss journey. Phentermine is meant to be combined with a calorie-restricted diet and regular exercise.
This medication comes in various oral forms, such as tablets, capsules, extended-release capsules, and disintegrating tablets, with dosages varying based on the formulation and individual needs. It is usually taken once daily in the morning. Due to its potential for misuse and dependence, Phentermine is classified as a Schedule IV controlled substance, although the risk is relatively low when used as directed.
Users often experience a reduced appetite within the first few days of starting the medication. Still, noticeable weight loss may take a few weeks and depends on adhering to a reduced-calorie diet and exercise plan.
Like any medication, Phentermine can cause side effects, including increased heart rate, elevated blood pressure, nervousness, dry mouth, and constipation. While serious side effects such as pulmonary hypertension and heart valve issues are rare, common mild side effects tend to diminish over time as the body adjusts to the medication.

Can You Experience Withdrawal From Phentermine?
People may face withdrawal symptoms from phentermine, especially after long-term use or high dosages. As a central nervous system stimulant, phentermine boosts the release of norepinephrine and dopamine, neurotransmitters that are involved in energy, mood, and appetite regulation.
With regular use, the body can become accustomed to the presence of phentermine to function normally, leading to dependency, which means if the medication is stopped abruptly, the person can experience withdrawal symptoms as the body readjusts to functioning without it.
Additionally, some individuals may develop a psychological dependence as they feel they need phentermine for energy, mood regulation, or appetite control, and can develop cravings and feelings of unease without it. While it’s not classified as a narcotic or illicit drug, it does have some similar stimulant effects to amphetamines, which can carry a risk of dependence and abuse, especially if it is used recreationally.
Although less common than with more potent stimulants like Adderall or methamphetamine, phentermine can be misused. Some individuals may increase their dose to intensify appetite suppression or stimulant effects.
Additionally, in larger doses, phentermine can produce euphoria as reported by SingleCare. Others may use phentermine alongside other stimulants like ADHD medications or caffeine pills to boost energy or suppress appetite further as well.
Misusing phentermine can increase the chances of dependence and experiencing more intense withdrawal symptoms. For this reason, doctors are not likely to prescribe phentermine to patients with a history of substance misuse or addiction.
What Are the Most Common Symptoms of Phentermine Withdrawal?
Individuals who take phentermine for only a few weeks are not likely to develop withdrawal symptoms. However, according to Healthline, misusing phentermine in higher doses or for long periods of time can cause dependence, leading to withdrawal symptoms when stopping use.
The severity and duration of withdrawal symptoms during treatment at Florida drug rehab centers can vary depending on factors like the dosage, duration of use, and an individual’s overall health. Some common phentermine withdrawal symptoms include:
- Fatigue or extreme tiredness
- Depression or mood changes
- Increased appetite
- Insomnia or sleep disturbances
- Irritability
- Anxiety
- Headaches
- Nausea or vomiting
- Cravings for the drug
Generally, individuals will begin to feel initial symptoms like fatigue, increased appetite, and mood changes within 24 to 72 hours after stopping the medication. Symptoms will intensify and peak within five to seven days, including irritability, headaches, and potential sleep disturbances. After 10 to 12 days, phentermine withdrawal symptoms will subside, but psychological symptoms like depression, anxiety, and cravings can linger much longer.

Are There Treatments That Can Help With Withdrawal?
To effectively manage the symptoms associated with phentermine withdrawal, there are several treatment options available to assist individuals during their recovery journey. Abruptly stopping phentermine can be challenging, but a gradual tapering-off approach under a healthcare provider’s guidance can help minimize withdrawal symptoms by allowing the body to readjust to the absence of the drug slowly.
While there are no specific medications approved for treating phentermine withdrawal, a blend of supportive therapies and medical supervision can significantly facilitate the process.
A medical detox program at a Florida drug rehab with private rooms can provide a safe, supervised environment where withdrawal symptoms can be monitored and managed. Physicians may prescribe medications to alleviate symptoms such as anxiety, depression, or insomnia, in conjunction with a tapering plan to make the withdrawal experience more manageable.
Ensuring sufficient rest and adhering to a nutritious, balanced diet is crucial for recovery. Nutritional guidance and behavioral therapies not only assist in restoring balance to the body and help individuals avoid weight gain after discontinuing phentermine.
Therapeutic approaches like Cognitive Behavioral Therapy (CBT) and Dialectical Behavior Therapy (DBT) can effectively tackle psychological issues such as depression, anxiety, and cravings. These therapies also help address the root causes of phentermine use and foster healthier attitudes towards food, body image, and substance use.
Engaging in nutritional counseling and exercise programs can provide individuals with non-pharmacological support for weight loss. Additionally, Support groups can foster a sense of belonging and shared experiences, helping to alleviate feelings of loneliness. Although dedicated phentermine withdrawal support groups may be rare, broader substance abuse or weight management groups can still be beneficial.
How WhiteSands Treatment Can Help Ease Phentermine Withdrawal Symptoms
Quitting phentermine abruptly can be both physically and emotionally exhausting. At WhiteSands Treatment in Florida, we recognize the difficulties associated with overcoming stimulant dependence and are committed to supporting you throughout the process. Our customized treatment programs offer the necessary structure, assistance, and medical expertise to help you safely manage phentermine withdrawal symptoms and avoid relapse.
We start with a medically supervised detox to ensure your safety and comfort as phentermine is eliminated from your body. Following detox, our compassionate and skilled team will create a personalized treatment plan that addresses co-occurring mental health challenges and the root causes of dependence through individual therapy, group counseling, holistic methods, and medication management.
Our rehabilitation centers in Florida offer a safe and inviting space for your recovery journey. Whether you are just beginning to recognize your dependence or have been battling phentermine or other stimulant addictions for years, we are here to help you embark on the path to a healthier, substance-free life.
Contact WhiteSands Treatment in Florida today at 877-855-3470 to connect with an admissions specialist and explore your treatment options.
External Sources
- GoodRx – What is Phentermine (Adipex-P)
- SingleCare – Common phentermine side effects in females
- Healthline – Side Effects of Phentermine Oral Forms: What You Need to Know
If you or a loved one needs help with abuse and/or treatment, please call the WhiteSands Treatment at (877) 855-3470. Our addiction specialists can assess your recovery needs and help you get the addiction treatment that provides the best chance for your long-term recovery.